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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Cryptic unstable transcript ： ウィキペディア英語版 Cryptic unstable transcript Cryptic Unstable Transcripts (CUTs) are a subset of non-coding RNAs (ncRNAs) that are produced from intergenic and intragenic regions. CUTs were first observed in ''S. cerevisiae'' yeast models and are found in most eukaryotes. Some basic characteristics of CUTs include a length of around 200-800 bp, a 5’ cap, poly-adenylated tail, and rapid degradation due to the combined activity of poly-adenylating polymerases and exosome complexes.〔 CUT transcription occurs through RNA Polymerase II and initiates from nucleosome-depleted regions, often in an antisense orientation.〔 To date, CUTs have a relatively uncharacterized function but have been implicated in a number of putative gene regulation and silencing pathways. Thousands of loci leading to the generation of CUTs have been described in the yeast genome. Additionally, Stable Uncharacterized Transcripts, or SUTs, have also been detected in cells and bear many similarities to CUTs but are not degraded through the same pathways. ==Discovery and Characterization of CUTS== Regions of non-coding RNA were mapped in several early experiments examining ''S. cerevisiae'' using a tiling array approach, which indicated that a large amount of transcriptional activity could be attributed to the intergenic region of the genome. These detected transcripts are not readily observed in the mRNA population because they are rapidly targeted for degradation in both the nucleus and cytoplasm.〔 However, CUTs can be examined in yeast mutants with compromised exosome enzyme capability, which allows for transcripts to accumulate and enables their study and characterization. In 2009, the Steinmetz and Jacquier laboratories performed a series of high-resolution transcriptome maps,〔 further characterizing the widespread distribution and location of non-coding transcripts within eukaryotes. CUTs were found to comprise around 13% of all mapped transcripts.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cryptic unstable transcript」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.